Chasty R C, Lamb W R, Gallati H, Roberts T E, Brenchley P E, Yin J A
Department of Haematology, Manchester Royal Infirmary, UK.
Bone Marrow Transplant. 1993 Oct;12(4):331-6.
Daily serum samples collected during 6 autologous and 13 allogeneic BMT were assayed retrospectively for tumour necrosis factor-alpha (TNF), interleukin-6 (IL-6) and C-reactive protein (CRP). In addition, for 6 allogeneic transplant patients soluble TNF receptor (sTNFR) levels were determined. IL-6 levels were regularly raised during febrile episodes and closely mirrored changes in serum CRP but were not predictive for non-infectious major transplant-related complications (TRC). Levels of TNF showed no such close association with infection and in contrast to previously reported data for allogeneic transplants having TRC, TNF levels were consistently detectable in only 3 of 9 patients. Pre-transplant levels were not predictive for the development of TRC and no profile was recognized to be specific for a particular complication. In transplants with only minor complications TNF levels remained consistently undetectable. sTNFR levels increased in a more stable manner in association with TRC, suggesting that they may be a more suitable marker to monitor major TRC.
对6例自体和13例异基因骨髓移植（BMT）期间采集的每日血清样本进行回顾性分析，检测肿瘤坏死因子-α（TNF）、白细胞介素-6（IL-6）和C反应蛋白（CRP）。此外，对6例异基因移植患者测定了可溶性TNF受体（sTNFR）水平。发热期间IL-6水平经常升高，与血清CRP变化密切相关，但不能预测非感染性主要移植相关并发症（TRC）。TNF水平与感染无此密切关联，与先前报道的发生TRC的异基因移植数据相反，9例患者中只有3例持续检测到TNF水平。移植前水平不能预测TRC的发生，也未发现特定并发症的特异性特征。在仅有轻微并发症的移植中，TNF水平始终未检测到。sTNFR水平与TRC相关，以更稳定的方式升高，表明它们可能是监测主要TRC的更合适标志物。
