Study of platelet aggregation in vivo i. Effect of bencyclan.
作者信息
Ambrus J L, Ambrus C M, Gastpar H, Sapvento P J, Weber F J, Thurber L E
出版信息
J Med. 1976;7(6):439-47.
PMID:827596
Abstract
A 20mu diameter pore size screen was inserted into an arterio-venous bypass system in heparinized stumptailed monkeys. ADP and serotonin injection resulted in aggregation of platelets on the screen and consecutive increase in pre-screen pressure and decrease in post-screen pressure. From these changes an "aggregation index" was calculated. Bencyclan in doses of 0.5-15 mg/kg inhibited platelet aggregation in vivo. Doses of 20 mg/kg or above showed some hemolytic effect, no other undesirable effects were seen.
摘要
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