Heath R G
J Neurol Neurosurg Psychiatry. 1976 Nov;39(11):1037-51. doi: 10.1136/jnnp.39.11.1037.
Against the background previous findings in epileptic patients, in whom electroencephalographic recordings were obtained from numerous deep and surface brain sites during seizures, rhesus monkeys with electrodes implanted into specific brain sites were used to demonstrate anatomical connections by evoked potential techniques and to serve as models of experimental epilepsy. In the animals, many monosynaptic connections were revealed between forebrain sites consistently involved in seizures in patients and more caudal brain sites subserving functions of sensory perception, eye movement, synaptic chemical transmission, and motor coordination. Further, the participation of these interrelated sites during seizures was demonstrated. The findings provide an anatomical-physiological explanation for many of the clinical phenomena observed in epileptic patients and a rationale for the use of cerebellar stimulation as a treatment.
基于先前对癫痫患者的研究发现，即在癫痫发作期间从多个深部和浅表脑区获取脑电图记录，将电极植入特定脑区的恒河猴被用于通过诱发电位技术证明解剖学联系，并作为实验性癫痫的模型。在这些动物中，在患者癫痫发作时始终涉及的前脑区域与更多尾侧脑区之间发现了许多单突触连接，这些尾侧脑区负责感觉感知、眼球运动、突触化学传递和运动协调功能。此外，还证明了这些相互关联的脑区在癫痫发作期间的参与情况。这些发现为癫痫患者中观察到的许多临床现象提供了解剖生理学解释，并为使用小脑刺激作为一种治疗方法提供了理论依据。
