Babb T L, Perryman K M, Lieb J P, Finch D M, Crandall P H
Electroencephalogr Clin Neurophysiol. 1979 Dec;47(6):725-37. doi: 10.1016/0013-4694(79)90300-6.
Intravenous procaine HCl given at low doses (0.5-2.5 mg/kg) to two monkeys with bilateral alumina hippocampal foci depressed interictal spiking or had little effect. At 5.0 mg/kg unilateral limbic activation occurred. At 10.0 mg/kg unilateral or bilateral limbic activation and generalized seizures could be evoked within 3-10 min. At higher doses (15 and 20 mg/kg) bilateral limbic activation or brief (one min) generalized seizures occurred. The unilateral-onset psychomotor seizures were not identical to spontaneous psychomotor seizures, and the generalized seizures never occurred spontaneously in these monkeys. However, these results do indicate that procaine challenges may selectively activate limbic epileptogenic areas without activation of debilitating generalized tonic-clonic seizures.
给两只患有双侧氧化铝海马病灶的猴子静脉注射低剂量（0.5 - 2.5毫克/千克）的盐酸普鲁卡因，可抑制发作间期的棘波发放，或几乎没有效果。剂量为5.0毫克/千克时会出现单侧边缘系统激活。剂量为10.0毫克/千克时，在3 - 10分钟内可诱发单侧或双侧边缘系统激活及全身性癫痫发作。更高剂量（15和20毫克/千克）时会出现双侧边缘系统激活或短暂（1分钟）全身性癫痫发作。单侧起病的精神运动性癫痫发作与自发性精神运动性癫痫发作不同，且这些猴子从未自发出现全身性癫痫发作。然而，这些结果确实表明，普鲁卡因激发试验可能会选择性激活边缘系统致痫区域，而不会激活使人衰弱的全身性强直阵挛性癫痫发作。
