Perutz M F
MRC Laboratory of Molecular Biology, Cambridge, UK.
Gene. 1993 Dec 15;135(1-2):9-13. doi: 10.1016/0378-1119(93)90041-z.
In the nineteen-thirties and -forties, genes were universally believed to be made of protein. Biochemists met Avery, MacLeod and McCarty's discovery, that the transforming factor of pneumococci consists of DNA, with disbelief, and the notion that this was true of genes took a long time to be generally accepted even after Watson and Crick's discovery of its double helical structure. Until Watson's arrival, Kendrew, Crick and I were interested mainly in solving the structure of proteins, but Watson made us think about the structure of genes which determine protein structure.
在20世纪30年代和40年代,人们普遍认为基因是由蛋白质构成的。生物化学家们对艾弗里、麦克劳德和麦卡蒂的发现,即肺炎球菌的转化因子是由DNA组成的,持怀疑态度。即使在沃森和克里克发现DNA的双螺旋结构之后,基因由DNA构成这一观点也花了很长时间才被普遍接受。在沃森到来之前,肯德鲁、克里克和我主要致力于解决蛋白质的结构问题,但沃森让我们开始思考决定蛋白质结构的基因的结构。