Kato H, Horai T, Furuse K, Fukuoka M, Suzuki S, Hiki Y, Ito Y, Mimura S, Tenjin Y, Hisazumi H
Department of Surgery, Tokyo Medical College.
Jpn J Cancer Res. 1993 Nov;84(11):1209-14. doi: 10.1111/j.1349-7006.1993.tb02823.x.
Photodynamic therapy utilizing Photofrin has proven to be an effective modality that can be used in the treatment of a wide variety of solid tumors and luminal cancers. An argon pumped dye laser or excimer dye laser was used to deliver 630 nm light via quartz fibers passed through the biopsy channel subsequent to i.v. injection of photosensitizer. In this study, 64 patients with superficial cancers were treated in this manner but only 58 patients, including 21 with roentgenographically occult lung cancer, 8 with stage I lung cancer, 5 with esophageal cancer, 12 with gastric cancer, 8 with cervical cancer and 4 with bladder cancer were evaluable. Complete remission was obtained in 48 out of 58 cases (82.8%). There was no serious complication except skin photosensitivity, which was seen in 13 patients. We conclude that photodynamic therapy is efficacious in the treatment of superficial cancers where complete remission may be achieved.
利用光敏剂卟啉进行的光动力疗法已被证明是一种有效的治疗方式，可用于治疗多种实体瘤和腔内癌。静脉注射光敏剂后，使用氩离子泵浦染料激光器或准分子染料激光器通过活检通道插入的石英光纤传输630纳米的光。在本研究中，64例浅表癌患者接受了这种治疗方式，但只有58例患者可评估，其中包括21例X线隐匿性肺癌、8例I期肺癌、5例食管癌、12例胃癌、8例宫颈癌和4例膀胱癌。58例患者中有48例（82.8%）获得完全缓解。除13例患者出现皮肤光敏反应外，无严重并发症。我们得出结论，光动力疗法在治疗可实现完全缓解的浅表癌方面是有效的。
