哈茨木霉产生的抗真菌代谢产物。

Antifungal metabolites from Trichoderma harzianum.

作者信息

Ghisalberti E L, Rowland C Y

机构信息

Department of Chemistry, University of Western Australia, Nedlands.

出版信息

J Nat Prod. 1993 Oct;56(10):1799-804. doi: 10.1021/np50100a020.

DOI:10.1021/np50100a020

PMID:8277317

Abstract

A detailed examination of the metabolites produced in liquid cultures by a strain of Trichoderma harzianum, isolated from wheat roots, has resulted in the identification of a further five metabolites. Two of these, cyclonerodiol [5] and the octaketide keto diol 6, have previously been isolated from a strain of Trichoderma koningii. The structures of the three new octaketide-derived compounds 7, 8, and 10 have been deduced from spectroscopic and chemical studies. All newly isolated compounds show antibiotic activity towards the take-all fungus, Gaeumannomyces graminis var. tritici.

摘要

对从小麦根部分离出的哈茨木霉菌株在液体培养物中产生的代谢产物进行详细研究后，又鉴定出了另外五种代谢产物。其中两种，环蛇麻二醇[5]和八酮基二醇6，先前已从康氏木霉菌株中分离出来。通过光谱和化学研究推断出了三种新的八酮衍生化合物7、8和10的结构。所有新分离出的化合物对全蚀病菌小麦变种都具有抗菌活性。