木霉醇，一种来自哈茨木霉F031的新型抗真菌剂。
Trichoharzianol, a new antifungal from Trichoderma harzianum F031.
作者信息
Jeerapong Chotika, Phupong Worrapong, Bangrak Phuwadol, Intana Warin, Tuchinda Patoomratana
机构信息
§Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
出版信息
J Agric Food Chem. 2015 Apr 15;63(14):3704-8. doi: 10.1021/acs.jafc.5b01258. Epub 2015 Apr 7.
A new decalin derivative, trichoharzianol (1), together with three known compounds, eujavanicol A (2), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (3), and 4,6-dihydroxy-5-methylphthalide (4), were isolated from Trichoderma harzianum F031. For the first time, compounds 2-4 were reported from the Trichoderma species. Their structures were characterized by spectroscopic methods. Trichoharzianol (1) showed the highest antifungal activity against Colletotrichum gloeosporioides, with a minimum inhibitory concentration (MIC) of 128 μg/mL.
从哈茨木霉F031中分离出一种新的十氢化萘衍生物曲古哈茨醇（1），以及三种已知化合物，即优香草酚A（2）、5-羟基-3-羟甲基-2-甲基-7-甲氧基色酮（3）和4,6-二羟基-5-甲基苯酞（4）。化合物2-4首次从木霉属物种中报道。它们的结构通过光谱方法进行了表征。曲古哈茨醇（1）对胶孢炭疽菌表现出最高的抗真菌活性，最低抑菌浓度（MIC）为128μg/mL。
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