The syndrome of accelerated bone maturation in the newborn infant with dysmorphism and congenital malformations. (The so-called Marshall-Smith syndrome).

A new case of the syndrome of "accelerated skeletal maturation, facial dysmorphism, failure to thrive and psychomotor retardation" is presented. The syndrome was noted in the neonatal period. The diagnosis can be readily suggested by the radiologist because ossification centers show exceptionally early maturation. This case history increases to at least five the number of cases so far reported following the initial publication by Marchall and al. in 1971. If the two cases described in 1974 by Weaver and al. (as a distinct entity) are also included then the total of cases reported rises to seven.