Yamasaki K, Otake T, Mori H, Morimoto M, Ueba N, Kurokawa Y, Shiota K, Yuge T
Osaka Prefectural Institute of Public Health, Japan.
Yakugaku Zasshi. 1993 Nov;113(11):818-24. doi: 10.1248/yakushi1947.113.11_818.
The anti-HIV-1 effects of 204 crude drugs of common use in Japan were evaluated in vitro. As a result, 45 samples inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In particular, the hot water extracts of Lithospermum erythrorhizon (root) and Prunella vulgaris (spike) showed the strongest anti-HIV-1 activities. Their IC100 values were both 16 micrograms/ml. In general, the hot water extracts of the crude drug suppressed the replication of HIV-1 growth more strongly than the cold water extracts.
对日本常用的204种天然药物的抗HIV-1作用进行了体外评估。结果，45个样品抑制了MT-4细胞中HIV-1诱导的细胞病变效应。特别地，紫草（根）和夏枯草（穗）的热水提取物显示出最强的抗HIV-1活性。它们的IC100值均为16微克/毫升。一般来说，天然药物的热水提取物比冷水提取物更能强烈抑制HIV-1的生长复制。
