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庚酸睾酮对正常男性造血功能的影响。

Effect of testosterone enanthate on hematopoiesis in normal men.

作者信息

Palacios A, Campfield L A, McClure R D, Steiner B, Swerdloff R S

出版信息

Fertil Steril. 1983 Jul;40(1):100-4. doi: 10.1016/s0015-0282(16)47185-2.

DOI:10.1016/s0015-0282(16)47185-2
PMID:6862037
Abstract

Testosterone enanthate, a commonly used depot form of androgen, was administered to normal men according to several dose schedules. This resulted in significant increments in serum testosterone levels despite the fact that testosterone concentrations remained within the normal population range in almost all instances. Mild but significant increases in white blood cell, red blood cell, hematocrit, and hemoglobin concentrations were noted. These effects correlated with the dose frequency schedules. Negligible changes in mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were observed. Despite the significant individual increases in blood parameters, all values remained within the normal population range and no clinical manifestations were observed.

摘要

庚酸睾酮是一种常用的雄激素长效注射剂,按照几种剂量方案给予正常男性。尽管在几乎所有情况下睾酮浓度仍处于正常人群范围内,但这导致血清睾酮水平显著升高。观察到白细胞、红细胞、血细胞比容和血红蛋白浓度有轻微但显著的增加。这些效应与给药频率方案相关。平均红细胞体积、平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度的变化可忽略不计。尽管血液参数有显著的个体增加,但所有数值仍在正常人群范围内,且未观察到临床表现。

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