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圣托马斯医院的孕妇风疹:是否有必要改变英国的疫苗接种政策?

Maternal rubella at St. Thomas' Hospital: is there a need to change British vaccination policy?

作者信息

Goldwater P N, Quiney J R, Banatvala J E

出版信息

Lancet. 1978 Dec 16;2(8103):1298-300. doi: 10.1016/s0140-6736(78)92055-x.

Abstract

During the 28 weeks starting April 3, 1978, 269 pregnant women were assessed serologically because of exposure to or development of rubella-like illnesses, this number being four times greater than that during either of the previous 2 years. Only 33 (12%) of these patients had previously been given rubella vaccine. Rubella was confirmed serologically in 17 patients; among patients attending antenatal clinics the overall risk of acquiring infection was about 1 in 155. The mean age of patients acquiring maternal rubella was 27.9 years, and all but 1 had left school before the rubella vaccination programme started. 55 (92%) of 60 household contacts were children, of whom 24 (40%) were of preschool age and 13 (21.7%) aged less than 2 years. The interval between contact and presentation for serological studies was often long and, because of this, 79 sera had to be tested for virus-specific IgM. No drastic change in rubella vaccination policy is required but there should be more emphasis on vaccination of women of childbearing age.

摘要

在1978年4月3日开始的28周内,269名孕妇因接触风疹样疾病或出现风疹样疾病症状而接受了血清学评估,这一数字是前两年中任何一年的四倍。这些患者中只有33人(12%)之前接种过风疹疫苗。血清学确诊风疹的患者有17人;在产前诊所就诊的患者中,感染风疹的总体风险约为1/155。感染风疹的孕妇平均年龄为27.9岁,除1人外,其他人在风疹疫苗接种计划开始前就已离校。60名家庭接触者中有55人(92%)是儿童,其中24人(40%)为学龄前儿童,13人(21.7%)年龄小于2岁。接触风疹后到进行血清学检查的时间间隔通常很长,因此,有79份血清需要检测病毒特异性IgM。风疹疫苗接种政策无需大幅改变,但应更加重视育龄妇女的疫苗接种。

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