Bordi Fabio, LeDoux Joseph, Clugnet Marie Christine, Pavlides Constantine
New York U, Ctr for Neural Science.
Behav Neurosci. 1993 Oct;107(5):757-769. doi: 10.1037/0735-7044.107.5.757.
Acoustic responses of single units were examined in awake, freely behaving rats in the lateral nucleus of the amygdala (AL). Recordings were made from a movable bundle of 9 microwires. Most cells had very low rates of spontaneous activity (about 3 spikes/s average). Firing rates increased during sleep states. Short-latency auditory responses (12-25 ms) were found in the dorsal subnucleus (ALd) of the AL. Cells in the ALd most typically responded in a sustained fashion. Some of the cells in the ALd showed preferences for high frequencies, tone bursts, or frequency-modulated stimuli with center frequencies above 12 kHz. Response latencies were considerably longer in other areas of the amygdala. Our results corroborate the main findings of a previous study (F. Bordi & J. LeDoux, 1992) that examined the acoustic response properties of single cells in the AL in anesthetized rats. Together the findings from awake and anesthetized rats provide the most precise information about sensory processing in amygdala neurons available to date.
在清醒、自由活动的大鼠杏仁核外侧核（AL）中检测单个神经元的听觉反应。记录由一束可移动的9根微丝完成。大多数细胞的自发放电率非常低（平均约3个峰/秒）。在睡眠状态下放电率会增加。在AL的背侧亚核（ALd）中发现了短潜伏期听觉反应（12 - 25毫秒）。ALd中的细胞最典型的反应方式是持续反应。ALd中的一些细胞对高频、短纯音或中心频率高于12千赫兹的调频刺激表现出偏好。杏仁核其他区域的反应潜伏期要长得多。我们的结果证实了之前一项研究（F. Bordi和J. LeDoux，1992）的主要发现，该研究检测了麻醉大鼠AL中单个细胞的听觉反应特性。清醒和麻醉大鼠的研究结果共同提供了迄今为止关于杏仁核神经元感觉处理的最精确信息。
