Chernyshev B V, Weinberger N M
Center for the Neurobiology of Learning and Memory, University of California, Irvine, Ca 92697-3800, USA.
Brain Res. 1998 May 18;793(1-2):79-94. doi: 10.1016/s0006-8993(98)00163-2.
The acoustic responses of cells in the basal forebrain were studied in the adult waking guinea pig. Frequency receptive fields were obtained across wide frequency (0.094-45.0 kHz) and intensity (0-90 dB) ranges. A total of 326 recordings were obtained in 26 electrode penetrations from five subjects; 205 from the globus pallidus (GP), 98 from the caudate-putamen (CPu) and 23 from the central nucleus of the amygdala (ACE). Twenty-nine recordings exhibited acoustic responses (GP=20 (9.8%); CPu=9 (9.2%); ACE=0). Cells in the regions of the GP that project to the primary auditory cortex (ACx) exhibited frequency tuning that was dominantly suppressive. Responses in the CPu were excitatory, but poorly tuned. The spontaneous rate of discharge of GP cells that yielded complete tuning data was positively correlated with power in the beta bands (12-25 and 25-50 Hz) and negatively correlated with power in the delta band (1-4 Hz) of the EEG of the ACx. These findings suggest that acoustically tuned neurons in the GP that are inhibited by tones are involved in the regulation of auditory cortical state, possibly promoting deactivation to unimportant sounds, and may be cholinergic in nature.
在成年清醒豚鼠中研究了基底前脑细胞的听觉反应。在较宽的频率（0.094 - 45.0千赫兹）和强度（0 - 90分贝）范围内获得了频率感受野。从5只实验对象的26次电极穿刺中总共获得了326次记录；205次来自苍白球（GP），98次来自尾状核 - 壳核（CPu），23次来自杏仁核中央核（ACE）。29次记录表现出听觉反应（GP = 20次（9.8%）；CPu = 9次（9.2%）；ACE = 0次）。投射到初级听觉皮层（ACx）的GP区域中的细胞表现出主要为抑制性的频率调谐。CPu中的反应是兴奋性的，但调谐较差。产生完整调谐数据的GP细胞的自发放电率与ACx脑电图的β频段（12 - 25和25 - 50赫兹）功率呈正相关，与δ频段（1 - 4赫兹）功率呈负相关。这些发现表明，GP中被音调抑制的听觉调谐神经元参与了听觉皮层状态的调节，可能促进对不重要声音的失活，并且其性质可能是胆碱能的。
