Ebisu T, Naruse S, Horikawa Y, Ueda S, Tanaka C, Uto M, Umeda M, Higuchi T
Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japan.
J Magn Reson Imaging. 1993 Nov-Dec;3(6):863-8. doi: 10.1002/jmri.1880030612.
Brain edema can be classified into three categories: vasogenic, cytotoxic, and interstitial. The mechanism of edema is thought to be different in each type. The authors studied the movement of water molecules in each type of white matter edema in a rat model by using diffusion-weighted magnetic resonance imaging. Conventional T2-weighted imaging did not allow distinction between the three types of white matter edema; the three types of edema were, however, distinguished by using diffusion-weighted imaging. The apparent diffusion coefficient (ADC) of water was different in each type of edema. Water molecules in cytotoxic edema induced by triethyl-tin intoxication showed a smaller and less anisotropic ADC than in normal white matter. In contrast, water in vasogenic edema induced by cold injury had a larger and more anisotropic ADC than in normal white matter. Water in interstitial edema due to kaolin-induced hydrocephalus had an anisotropic and very large ADC.
血管源性、细胞毒性和间质性。每种类型的水肿机制被认为有所不同。作者通过使用扩散加权磁共振成像，在大鼠模型中研究了每种类型白质水肿中水分子的运动。传统的T2加权成像无法区分三种类型的白质水肿；然而，通过使用扩散加权成像可以区分这三种类型的水肿。每种类型水肿中水分子的表观扩散系数（ADC）有所不同。三乙锡中毒所致细胞毒性水肿中的水分子，其ADC值比正常白质中的更小且各向异性更弱。相比之下，冷损伤所致血管源性水肿中的水，其ADC值比正常白质中的更大且各向异性更强。高岭土诱导的脑积水所致间质性水肿中的水，其ADC值各向异性且非常大。
