Wallenstein F A, Ringelmann R
Immun Infekt. 1976 Dec;4(6):276-8.
5,589 urin samples from patients with suspected infections of the urinary tract were screened for inhibiting activity against Baz. cereus (ATCC 6051). In 19% of these urines such inhibitors could be found. In spite of the antibacterial inhibition activity nearly half of the samples had bacteria in high number. By comparison of the various bacterial species in both groups of urin, in those without antibacterial "Problem-Bacteria": Klebsiella-Enterobacter- Proteus- Candida-species is demonstrated. If one compares the urine of the same patient before and under chemotherapie it seems as if antibiotic therapie is often started without proof of significant bacteriuria. In those patients, where there was a significant bacteriuria in the first urine sample only 7 from 20 showed sterile urine under chemotherapie; 10 patients had an other species in the second sample and 3 patients had the same species isolated from urine during therapie. The diagnosis and the consequences especially for therapie in stationary patients with recurrent infections is discussed.
对5589份疑似尿路感染患者的尿液样本进行了检测，以筛选其对蜡样芽孢杆菌（ATCC 6051）的抑制活性。在19%的尿液样本中发现了此类抑制剂。尽管有抗菌抑制活性，但近一半的样本中细菌数量仍很高。通过比较两组尿液中的各种细菌种类，在没有抗菌作用的样本中发现了“问题细菌”：克雷伯菌属 - 肠杆菌属 - 变形杆菌属 - 念珠菌属。如果比较同一患者化疗前和化疗期间的尿液，似乎抗生素治疗常常在未证实有明显菌尿的情况下就开始了。在那些首次尿液样本中有明显菌尿的患者中，20例中只有7例在化疗期间尿液无菌；10例患者的第二个样本中有其他菌种，3例患者在治疗期间尿液中分离出相同的菌种。文中讨论了对于患有复发性感染的住院患者的诊断及其对治疗的影响。
