Besançon G, Servillat T, Albert E
Service Hospitalo-Universitaire de Psychiatrie et Psychologie Médicale, Hôpital Saint-Jacques, Nantes.
Encephale. 1993 Mar;19 Spec No 1:203-7.
Speaking of "drugs of stress" is difficult because stress is not a so precise concept. Moreover, the target is not simply the correction of physiological responses to a stimulus, but is the treatment of pathologies which are directly related with stress: post-traumatic stress disorders (PTSD) and performance anxiety. Drug treatment of PTSD is not well codified, even if phenelzine and amitriptyline are, at least relatively, effective medicines. Beta-blockers remain today the main drugs for performance anxiety. Studies about the utility of carbamazepine and clonidine in these disorders are few. Experimental works upon the action of tianeptine on hippocampus cells lead to interesting results. The place of benzodiazepines and neuroleptics is still controversial.
提及“应激药物”颇具难度，因为应激并非一个十分精确的概念。此外，目标并非仅仅是纠正对刺激的生理反应，而是治疗与应激直接相关的病症：创伤后应激障碍（PTSD）和表演焦虑症。PTSD的药物治疗尚无完善的规范，即便苯乙肼和阿米替林至少相对而言是有效的药物。β受体阻滞剂至今仍是治疗表演焦虑症的主要药物。关于卡马西平和可乐定在这些病症中的效用的研究较少。对噻奈普汀作用于海马体细胞的实验研究得出了有趣的结果。苯二氮䓬类药物和抗精神病药物的地位仍存在争议。
