Hunt R D, Van Zwieten M J, Baggs R B, Sehgal P K, King N W, Roach S M, Blake B J
Lab Anim Sci. 1976 Dec;26(6 Pt 2):1088-92.
Glomerular disease was observed in 45 of 57 owl monkeys (Aotus trivirgatus). The disease was minimal in eight of the affected animals and moderate to extensive with respect to severity of the lesions and the number of glomeruli involved in the remainder. The lesions were characterized by proliferation and hypertrophy of mesangial and epithelial cells, increase in mesangial matrix, thickening of basement membranes, and sclerosis. Immunofluorescent staining suggested that the disease was an immune complex glomerulonephritis.
在57只夜猴（Aotus trivirgatus）中，有45只观察到肾小球疾病。在8只受影响的动物中，疾病程度较轻，其余动物的病变严重程度和受累肾小球数量则为中度至广泛。病变的特征是系膜细胞和上皮细胞增生、肥大，系膜基质增加，基底膜增厚和硬化。免疫荧光染色表明该疾病是一种免疫复合物性肾小球肾炎。
