Albaladejo P, Bouaziz H, Duriez M, Gohlke P, Levy B I, Safar M E, Benetos A
INSERM U337, Broussais Hospital, Paris, France.
Hypertension. 1994 Jan;23(1):74-82. doi: 10.1161/01.hyp.23.1.74.
Four groups of 4-week-old spontaneously hypertensive rats were treated during 4 months with the angiotensin converting enzyme inhibitor quinapril at 1 mg/kg per day (Q1) or 10 mg/kg per day (Q10), hydralazine at 15 mg/kg per day (H), or placebo (P). In the first set of experiments, blood pressure was measured in conscious rats, and plasma and aortic angiotensin converting enzyme activities were evaluated. In the second set of experiments, histomorphometric parameters of the thoracic aorta were evaluated. Mean blood pressure was lower in the Q10 and H groups (136 +/- 16 and 149 +/- 11 mm Hg) compared with the P group (190 +/- 23 mm Hg) (P < .01). The Q1 group showed mean blood pressure values (171 +/- 15 mm Hg) lower than the P group (P < .05) but significantly higher than the Q10 and H groups (P < .01 and P < .05, respectively). Aortic medial cross-sectional area was significantly lower in the H and Q10 groups (455 +/- 61 and 487 +/- 57 x 10(3) microns 2) than in the P group (636 +/- 72 x 10(3) microns 2) (P < .001).(ABSTRACT TRUNCATED AT 250 WORDS)
将四组4周龄的自发性高血压大鼠，分别用血管紧张素转换酶抑制剂喹那普利（每天1毫克/千克，Q1组；或每天10毫克/千克，Q10组）、每天15毫克/千克的肼屈嗪（H组）或安慰剂（P组）进行为期4个月的治疗。在第一组实验中，测量清醒大鼠的血压，并评估血浆和主动脉血管紧张素转换酶活性。在第二组实验中，评估胸主动脉的组织形态计量学参数。与P组（190±23毫米汞柱）相比，Q10组和H组的平均血压较低（分别为136±16和149±11毫米汞柱）（P<.01）。Q1组的平均血压值（171±15毫米汞柱）低于P组（P<.05），但显著高于Q10组和H组（分别为P<.01和P<.05）。H组和Q10组的主动脉中膜横截面积（分别为455±61和487±57×10³平方微米）显著低于P组（636±72×10³平方微米）（P<.001）。（摘要截短于250字）
