Sanderson J E, Olsen E G, Gatei D
Department of Medicine, St Mary's Hospital Medical School, London, UK.
Int J Cardiol. 1993 Sep;41(2):157-63. doi: 10.1016/0167-5273(93)90156-b.
We have studied, by light and electron microscopy, left ventricular endomyocardial biopsy specimens from 18 African patients (14 men) with idiopathic dilated cardiomyopathy in Nairobi. Nine patients (50%) had evidence of healing myocarditis, that is the presence of a mild inflammatory cell infiltration within the myocardium. Interstitial fibrosis was prominent in five patients (28%) and in all 18 specimens there were hypertrophied muscle fibres. Therefore, half of the patients with idiopathic dilated cardiomyopathy had histological signs of a previous myocarditis. There was no serological evidence of a previous or recent coxsackie infection or any other common viral infections. It seems probable that the myocarditis was due to an inappropriate immunological reaction to myocardial muscle.
我们通过光学显微镜和电子显微镜，研究了来自内罗毕18例特发性扩张型心肌病非洲患者（14名男性）的左心室心内膜活检标本。9例患者（50%）有愈合性心肌炎的证据，即心肌内存在轻度炎性细胞浸润。5例患者（28%）间质纤维化明显，在所有18个标本中均有肥大的肌纤维。因此，一半的特发性扩张型心肌病患者有既往心肌炎的组织学迹象。没有既往或近期柯萨奇感染或任何其他常见病毒感染的血清学证据。心肌炎似乎可能是由于对心肌的不适当免疫反应所致。
