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母乳喂养与婴儿猝死综合征风险

Breastfeeding and the risk of sudden infant death syndrome.

作者信息

Ford R P, Taylor B J, Mitchell E A, Enright S A, Stewart A W, Becroft D M, Scragg R, Hassall I B, Barry D M, Allen E M

机构信息

Community Paediatric Unit, Christchurch, New Zealand.

出版信息

Int J Epidemiol. 1993 Oct;22(5):885-90. doi: 10.1093/ije/22.5.885.

DOI:10.1093/ije/22.5.885
PMID:8282468
Abstract

The New Zealand Cot Death Study, a multicentre case-control study, was set up to identify risk factors associated with sudden infant death syndrome (SIDS). In the 3 years of the study there were 485 infant deaths classified as SIDS in the study areas and 1800 infants who were randomly selected as controls. Data were collected by parent interviews and from obstetric notes. A full set of data for this analysis was available from 356 cases and 1529 control infants. The relationship between length of any breastfeeding and SIDS was examined: 92% of the controls were initially breastfed compared to 86% of the cases. As time went by, cases stopped breastfeeding sooner than controls: by 13 weeks, 67% controls were breastfed versus 49% cases. A reduced risk for SIDS in breastfed infants persisted during the first 6 months after controlling for confounding demographic, maternal and infant factors. Infants exclusively breastfed 'at discharge from the obstetric hospital' (odds ratio [OR] = 0.52, 95% confidence interval (CI): 0.35-0.71) and during the last 2 days (OR = 0.65, 95% CI: 0.46-0.91) had a significantly lower risk of SIDS than infants not breastfed after controlling for potential confounders. We have shown a substantial association of breastfeeding with a lowered risk for SIDS. This supports the need for more positive promotion and active community support to further enhance the level and length of exclusive breastfeeding.

摘要

新西兰婴儿猝死研究是一项多中心病例对照研究,旨在确定与婴儿猝死综合征(SIDS)相关的风险因素。在研究的3年中,研究区域内有485例婴儿死亡被归类为SIDS,另有1800名婴儿被随机选为对照组。数据通过对父母的访谈以及产科记录收集。本次分析的完整数据集来自356例病例和1529名对照婴儿。研究了任何母乳喂养时长与SIDS之间的关系:92%的对照组婴儿最初接受母乳喂养,而病例组这一比例为86%。随着时间推移,病例组比对照组更早停止母乳喂养:到第13周时,67%的对照组婴儿仍在接受母乳喂养,而病例组这一比例为49%。在控制了混杂的人口统计学、母亲和婴儿因素后,母乳喂养婴儿在出生后头6个月内SIDS风险降低的情况持续存在。在控制了潜在混杂因素后,“产科医院出院时”纯母乳喂养的婴儿(优势比[OR]=0.52,95%置信区间(CI):0.35 - 0.71)以及在最后2天纯母乳喂养的婴儿(OR = 0.65,95% CI:0.46 - 0.91)患SIDS的风险显著低于未母乳喂养的婴儿。我们已经表明母乳喂养与降低SIDS风险之间存在显著关联。这支持了需要更积极地推广并获得社区积极支持,以进一步提高纯母乳喂养的水平和时长。

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