华氏巨球蛋白血症中血红蛋白估计不准确：与单体IgM副蛋白的异常反应。
Inaccurate haemoglobin estimation in Waldenström's macroglobulinaemia: unusual reaction with monomeric IgM paraprotein.
作者信息
Goodrick M J, Boon R J, Bishop R J, Copplestone J A, Prentice A G
机构信息
Department of Haematology, Derriford Hospital, Plymouth.
出版信息
J Clin Pathol. 1993 Dec;46(12):1138-9. doi: 10.1136/jcp.46.12.1138.
Automated blood counts from a patient with Waldenström's macroglobulinaemia repeatedly failed critical limit standards set for mean cell haemoglobin concentration and mean cell haemoglobin. Haemoglobin estimation was higher than that suggested by clinical examination, symptoms, and the spun haematocrit. This was found to be due to an interaction between the Coulter lysing agent and monomeric IgM paraprotein in the patient's plasma, creating a precipitate which was optically dense at 525 nm.
一位患有华氏巨球蛋白血症患者的自动血细胞计数多次未达到针对平均红细胞血红蛋白浓度和平均红细胞血红蛋白设定的临界限值标准。血红蛋白估计值高于临床检查、症状及离心血细胞比容所提示的值。发现这是由于库尔特溶血剂与患者血浆中的单体IgM副蛋白之间相互作用，产生了一种在525nm处具有光密度的沉淀物。
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