De Gottrau P, Holbach L M, Naumann G O
Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg.
J Fr Ophtalmol. 1993;16(8-9):493-6.
Fungal keratitis is a rare disease in Northern Europe. We report the case of a 57-year-old female suffering from a paracentral corneal ulcer, following minor corneal trauma with a branch of a tree. Clinically, the ulcer was associated with a ring infiltrate and a hypopyon. Corneal smears and cultures were negative. As the corneal lesions and the hypopyon progressed despite maximal treatment, penetrating keratoplasty was performed on the assumption of a fungal origin. Histopathologic examination revealed pseudohyphae, morphologically compatible with a candida species. The clinical picture, its differential diagnosis and the diagnostic methods are discussed.
真菌性角膜炎在北欧是一种罕见疾病。我们报告一例57岁女性病例，该患者在被树枝轻微擦伤角膜后发生了角膜旁中央溃疡。临床上，溃疡伴有环形浸润和前房积脓。角膜涂片和培养均为阴性。尽管进行了最大程度的治疗，但角膜病变和前房积脓仍在进展，基于真菌起源的假设进行了穿透性角膜移植术。组织病理学检查发现假菌丝，形态上与念珠菌属相符。本文讨论了该病例的临床表现、鉴别诊断及诊断方法。
