Nagy I, Hajnal F, Mohácsi G, Németh J, Lászik Z, Pap A
1st Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Int J Pancreatol. 1993 Oct;14(2):157-66. doi: 10.1007/BF02786122.
Pancreatic trophism and pancreatic enzyme composition, and plasma levels of cholecystokinin, insulin, glucagon, and glucose in liver cirrhosis induced by chronic thioacetamide administration (0.02% in the drinking water for 12 mo) were studied in rats. Advanced liver cirrhosis was evident in all thioacetamide-treated rats. The weight of the pancreas and its contents of DNA, protein, trypsinogen, chymotrypsinogen, proelastase, secretory trypsin inhibitor, and amylase were significantly increased as compared to the controls. The pancreatic secretory enzyme content changes showed a nonparallelism, characteristic of a cholecystokinin effect. Light and electron microscopy revealed a normal pancreatic architecture. Bioassayed plasma cholecystokinin levels in both fed and 24-h-fasted cirrhotic rats were significantly higher than in the corresponding controls. The plasma glucose, insulin, and glucagon levels demonstrated hypoglycemic tendencies with a glucagon predominance. These findings indicate that advanced liver cirrhosis in the rat is accompanied by pancreatic hypertrophy and hyperplasia, which might be attributed, at least in part, to elevated circulating cholecystokinin levels.
研究了通过慢性给予硫代乙酰胺（饮用水中含0.02%，持续12个月）诱导肝硬化的大鼠的胰腺营养状况、胰腺酶组成以及血浆中胆囊收缩素、胰岛素、胰高血糖素和葡萄糖的水平。所有硫代乙酰胺处理的大鼠均出现晚期肝硬化。与对照组相比，胰腺重量及其DNA、蛋白质、胰蛋白酶原、糜蛋白酶原、弹性蛋白酶原、分泌性胰蛋白酶抑制剂和淀粉酶的含量均显著增加。胰腺分泌酶含量的变化显示出不平行性，这是胆囊收缩素作用的特征。光镜和电镜检查显示胰腺结构正常。喂食和禁食24小时的肝硬化大鼠经生物测定的血浆胆囊收缩素水平均显著高于相应对照组。血浆葡萄糖、胰岛素和胰高血糖素水平呈现低血糖倾向，以胰高血糖素占主导。这些发现表明，大鼠晚期肝硬化伴有胰腺肥大和增生，这可能至少部分归因于循环中胆囊收缩素水平的升高。
