Takeda T, Kimura M, Itokawa Y
Department of Hygiene, Faculty of Medicine, Kyoto University, Japan.
J Nutr Sci Vitaminol (Tokyo). 1993 Aug;39(4):355-63. doi: 10.3177/jnsv.39.355.
Female Wistar rats were separated into 9 groups, and 9 different synthetic diets (each diet contains different level of protein and calcium) were given to each group. After 5 weeks of these dietary regimens, all rats were sacrificed and calcium, magnesium, and phosphorus levels in plasma and various tissues were determined. In calcium-deficient groups, calcium, magnesium, and phosphorus level in bone decreased, plasma calcium level decreased and there was a tendency that magnesium levels in brain and liver and phosphorus level in brain increased. When comparison was made among the calcium-deficient groups, calcium, magnesium, and phosphorus levels in bone were higher in low protein/calcium-deficient group than higher protein/calcium-deficient groups. It is probable that protein deficiency inhibits calcium depletion and consequently the influence of calcium deficiency is less significant in the condition of deficiency in both protein and calcium.
将雌性Wistar大鼠分为9组，给每组喂食9种不同的合成饲料（每种饲料含有不同水平的蛋白质和钙）。在这些饮食方案实施5周后，处死所有大鼠，并测定血浆和各种组织中的钙、镁和磷水平。在缺钙组中，骨骼中的钙、镁和磷水平降低，血浆钙水平降低，并且脑和肝脏中的镁水平以及脑中的磷水平有升高的趋势。当在缺钙组之间进行比较时，低蛋白/缺钙组骨骼中的钙、镁和磷水平高于高蛋白/缺钙组。蛋白质缺乏可能会抑制钙的消耗，因此在蛋白质和钙都缺乏的情况下，缺钙的影响不太显著。
