Ikenaga M, Ohura K, Yamamuro T, Kotoura Y, Oka M, Kokubo T
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
J Orthop Res. 1993 Nov;11(6):849-55. doi: 10.1002/jor.1100110611.
Localized hyperthermic treatment was carried out with use of a metastatic bone tumor model in rabbits. The experimental bone tumor was created by transplantation of pieces of tumor line VX2 into the medullary canal of rabbit tibiae. Two weeks after the transplantation, a ferromagnetic ceramic pin was inserted in the medullary canal. Then, hyperthermia (HT) of the tumor was accomplished with use of an alternating magnetic field for 50 min. All the rabbits were killed 5 weeks after tumor transplantation, and the therapeutic effect was evaluated histologically and roentgenographically. Almost all the tumor cells within the bone marrow were killed by this procedure. The area of tumor necrosis in the HT group was significantly larger than in the control group. The pathological fracture rate and displacement rate were reduced significantly by this treatment (38.5 and 0%) compared with the controls (92.3 and 92.3%). Therefore, HT with the use of ferromagnetic ceramics was effective for local control of malignant bone tumors and seems to be a promising new method of treatment.
利用兔转移性骨肿瘤模型进行局部热疗。通过将VX2肿瘤组织块移植到兔胫骨骨髓腔来建立实验性骨肿瘤。移植两周后，将一根铁磁陶瓷针插入骨髓腔。然后，使用交变磁场对肿瘤进行50分钟的热疗。所有兔子在肿瘤移植后5周处死，通过组织学和X线检查评估治疗效果。该方法几乎杀死了骨髓内所有肿瘤细胞。热疗组肿瘤坏死面积明显大于对照组。与对照组（92.3%和92.3%）相比，该治疗显著降低了病理性骨折率和移位率（分别为38.5%和0%）。因此，使用铁磁陶瓷进行热疗对恶性骨肿瘤的局部控制有效，似乎是一种有前景的新治疗方法。
