Ohura K, Ikenaga M, Nakamura T, Yamamuro T, Ebisawa Y, Kokubo T, Kotoura Y, Oka M
Department of Orthopaedic Surgery, Kyoto University, Japan.
J Appl Biomater. 1991 Fall;2(3):153-9. doi: 10.1002/jab.770020303.
Glass plates of the chemical composition: CaO (29.0), SiO 2 (31.0), Fe 2O 3 (40.0), B 2O 3 (3.0), P 2O 5 (3.0) in weight ratio were heated to 1050 degrees C at a rate of 5 degrees C/min and then cooled to laboratory temperature. The resulting glass-ceramic containing magnetite and wollastonite crystals showed high-saturation magnetization. The bonding ability of this new glass-ceramic to bone tissue was evaluated using rabbit tibiae, and compared with glass of the same composition. This glass-ceramic formed a Ca, P-rich layer on its surface and bonded tightly with bone within 8 weeks of implantation. However, the glass did not form this Ca, P-rich layer, nor had it bonded with bone at 25 weeks. The bone-heating ability of this glass-ceramic was investigated by applying a max. 300-Oe, 100-kHz magnetic field. The granules of the glass-ceramic filled in the rabbit tibiae heated the whole surrounding bone to more than 42 degrees C and maintained this temperature for 30 min. Bioactive ceramics reinforce the mechanical strength of bone tissue. Furthermore, this heat-generating bioactive glass-ceramic can be used for hyperthermic treatment of bone tumors.
CaO（29.0）、SiO₂（31.0）、Fe₂O₃（40.0）、B₂O₃（3.0）、P₂O₅（3.0）的玻璃板以5℃/分钟的速率加热至1050℃，然后冷却至室温。所得含有磁铁矿和硅灰石晶体的微晶玻璃显示出高饱和磁化强度。使用兔胫骨评估这种新型微晶玻璃与骨组织的结合能力，并与相同成分的玻璃进行比较。这种微晶玻璃在其表面形成了富含钙、磷的层，并在植入8周内与骨紧密结合。然而，该玻璃未形成这种富含钙、磷的层，并且在25周时也未与骨结合。通过施加最大300 Oe、100 kHz的磁场来研究这种微晶玻璃的骨加热能力。填充在兔胫骨中的微晶玻璃颗粒将整个周围的骨加热到42℃以上，并将该温度维持30分钟。生物活性陶瓷增强骨组织的机械强度。此外，这种产生热量的生物活性微晶玻璃可用于骨肿瘤的热疗。
