Takata T, Ogawa I, Miyauchi M, Ijuhin N, Nikai H, Fujita M
Clinical Laboratory, Hiroshima University School of Dentistry, Japan.
J Oral Pathol Med. 1993 Sep;22(8):378-83. doi: 10.1111/j.1600-0714.1993.tb01093.x.
A rare case of calcifying epithelial odontogenic tumor (CEOT) devoid of calcification is reported with histochemical, immunohistochemical and electron microscopic studies. The tumor occurred intraosseously in the left maxillary canine and premolar region of a 58-year-old man. The tumor chiefly consisted of scattered small islands of epithelial cells in an abundant fibro-myxoid connective tissue stroma. Among the nests, there were many spherical bodies of eosinophilic substance for which non-AA amyloid and non-keratin or basal lamina-like natures were demonstrated histochemically and immunohistochemically. In some nests, there were a few, occasionally several, cells positive for S-100 protein. Ultrastructurally, Langerhans cells with indented nuclei and Birbeck's granules were seen among tumor cells. The prognostic significance of the paucity of calcification and the presence of Langerhans cells in CEOT of which this is only the second description is discussed.
本文通过组织化学、免疫组织化学及电子显微镜研究，报道了一例罕见的无钙化的牙源性钙化上皮瘤（CEOT）。该肿瘤发生于一名58岁男性左侧上颌尖牙和前磨牙区域的骨内。肿瘤主要由散在的小上皮细胞岛组成，位于丰富的纤维黏液样结缔组织基质中。在细胞巢中，有许多嗜酸性物质的球形小体，组织化学和免疫组织化学显示其性质既非AA淀粉样蛋白，也非角蛋白或基底膜样物质。在一些细胞巢中，有少数（偶尔有几个）细胞S-100蛋白呈阳性。超微结构观察发现，肿瘤细胞中有核呈凹陷状的朗格汉斯细胞及伯贝克颗粒。本文讨论了该仅为第二例报道的CEOT中钙化缺乏及朗格汉斯细胞存在的预后意义。
