Gopalakrishnan Rajaram, Simonton Susan, Rohrer Michael D, Koutlas Ioannis G
Division of Oral and Maxillofacial Pathology, School of Dentistry, University of Minnesota, Saint Paul, MN, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Dec;102(6):773-7. doi: 10.1016/j.tripleo.2005.09.029. Epub 2006 Jul 11.
Calcifying epithelial odontogenic tumor (CEOT) is a benign, locally aggressive odontogenic neoplasm characterized by sheets and nests of epithelial cells with deeply eosinophilic or occasionally clear cytoplasm, calcifications, and eosinophilic amorphous material that stains positive for amyloid. Although many cases of CEOT are associated with impacted teeth and occasionally appear radiographically as dentigerous cysts, a true cystic variant has not been previously reported. We report a 15-year-old white male with a large cystic maxillary lesion that filled most of the left maxillary sinus. It deformed the medial wall, the inferior orbital floor, and caused narrowing of the left inferior meatus. Histologically, the cystic lining showed characteristics of CEOT. An intraluminal component that featured histologic characteristics of CEOT was identified during surgery. The lesion was enucleated and the postsurgical course of the patient was uneventful. Because follow-up has been for less than 1 year, a meaningful long-term prognosis cannot be determined at present. However, the patient has not reported any symptoms or signs of recurrence during the follow-up period.
牙源性钙化上皮瘤（CEOT）是一种良性、具有局部侵袭性的牙源性肿瘤，其特征为上皮细胞呈片状和巢状排列，细胞质嗜酸性深染，偶尔呈透明状，有钙化，还有对淀粉样蛋白染色呈阳性的嗜酸性无定形物质。尽管许多牙源性钙化上皮瘤病例与阻生牙有关，偶尔在影像学上表现为含牙囊肿，但此前尚未报道过真正的囊性变体。我们报告一例15岁白人男性，其左侧上颌骨有一个巨大的囊性病变，占据了大部分左上颌窦。它使内侧壁、眶下壁变形，并导致左侧下鼻道狭窄。组织学上，囊肿内衬显示出牙源性钙化上皮瘤的特征。手术中发现腔内成分具有牙源性钙化上皮瘤的组织学特征。病变被摘除，患者术后恢复顺利。由于随访时间不足1年，目前无法确定有意义的长期预后。然而，患者在随访期间未报告任何复发的症状或体征。
