Kato C, Sato K, Toyama J, Kano A
First Department of Internal Medicine, Iwate Medical University.
Nihon Rinsho. 1993 Dec;51(12):3192-5.
In order to elucidate bacterial infection, as a rule, isolated and cultured bacteria of a specimen are identified by their morphologies or biochemical characteristics. However, the culture of Helicobacter pylori (H. pylori) is difficult and takes, much time. Therefore, favorable test results are currently obtained by combining the culture method, histopathologic method, urease test and sero-immunologic test. The merits of the urease test are that judgement is available immediately after endoscopy and that the test is inexpensive. The demerits are that the existence of H. pylori is diagnosed only by estimation that endoscopy is indispensable for the test. When compared with the culture method, the urease test has 91.8% sensitivity and 94.7% specificity and when compared with the histopathologic method, it has 94.4% sensitivity 88.4% specificity. In the future, the clinical requirement will increase for quick investigation on the evidence of H. pylori-induced infection. These results show that urease test is useful because it is simple and allows quick judgement.
为了阐明细菌感染，通常通过形态学或生化特征对从标本中分离培养出的细菌进行鉴定。然而，幽门螺杆菌（H. pylori）的培养困难且耗时。因此，目前通过结合培养法、组织病理学方法、尿素酶试验和血清免疫学试验可获得良好的检测结果。尿素酶试验的优点是在内镜检查后可立即做出判断且检测成本低廉。缺点是仅通过推测诊断幽门螺杆菌的存在，且内镜检查对于该检测必不可少。与培养法相比，尿素酶试验的敏感性为91.8%，特异性为94.7%；与组织病理学方法相比，其敏感性为94.4%，特异性为88.4%。未来，对幽门螺杆菌感染证据进行快速检测的临床需求将会增加。这些结果表明尿素酶试验很有用，因为它操作简单且能快速做出判断。
