Aoyama N, Shirasaka D
Department of Endoscopy, Kobe University School of Medicine.
Nihon Rinsho. 2001 Feb;59(2):273-9.
The rapid urease test is a simple, sensitive, and highly specific test that enables the endoscopist to diagnose Helicobacter pylori infection in the endoscopy room. Determination of the infection status of Helicobacter pylori by biopsies from the gastric body had a significantly higher sensitivity than antral biopsies. A false-negative reaction by rapid urease test occurred the use of antibiotics (correlates with clearance of the bacteria) and the use of proton pump inhibitor or a part of mucosal protective agents(correlates urease inhibitory effect) and in the case of non-urease producing Helicobacter pylori. The rapid urease test satisfactory overall sensitivity before eradication treatment. However, the sensitivity of these rapid urease tests was lower after eradication than before eradication.
快速尿素酶试验是一种简单、灵敏且高度特异的检测方法，能让内镜医师在内镜检查室诊断幽门螺杆菌感染。通过胃体活检确定幽门螺杆菌感染状况的敏感性显著高于胃窦活检。快速尿素酶试验出现假阴性反应的情况有：使用抗生素（与细菌清除相关）、使用质子泵抑制剂或部分黏膜保护剂（与尿素酶抑制作用相关）以及存在不产生尿素酶的幽门螺杆菌。在根除治疗前，快速尿素酶试验总体敏感性良好。然而，这些快速尿素酶试验在根除治疗后的敏感性低于根除治疗前。
