Steiner C A, Bass E B, Talamini M A, Pitt H A, Steinberg E P
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
N Engl J Med. 1994 Feb 10;330(6):403-8. doi: 10.1056/NEJM199402103300607.
Since 1989, laparoscopic cholecystectomy has been widely adopted as a treatment for gallstone disease. We analyzed the association between the introduction of this procedure and three variables: the rate at which cholecystectomy was performed in Maryland, the characteristics of patients undergoing cholecystectomy in routine clinical practice, and operative mortality.
We used 1985-1992 hospital-discharge data from all 54 acute care hospitals in Maryland, to identify open and laparoscopic cholecystectomies, characteristics of patients undergoing these procedures, and deaths occurring during hospitalizations in which these procedures were performed. The annual rate of cholecystectomy, adjusted for age, rose from 1.69 per 1000 state residents in 1987-1989 to 2.17 per 1000 residents in 1992, an increase of 28 percent (P < 0.001). As compared with patients undergoing open cholecystectomy, patients undergoing laparoscopic cholecystectomy tended to be younger, less likely to have acute cholecystitis or a common-duct stone, and more likely to be white and have private health insurance or belong to a health maintenance organization (P < 0.001). Although the operative mortality associated with laparoscopic cholecystectomy was less than that with open cholecystectomy (adjusted odds ratio, 0.22; 95 percent confidence interval, 0.13 to 0.37) and the overall mortality rate for all cholecystectomies declined from 0.84 percent in 1989 to 0.56 percent in 1992, there was no significant change in the total number of cholecystectomy-related operative deaths because of the increase in the cholecystectomy rate.
In Maryland, although the adoption of laparoscopic cholecystectomy has been accompanied by a 33 percent decrease in overall operative mortality per procedure, the total number of cholecystectomy-related deaths has not fallen because of a 28 percent increase in the total rate of cholecystectomy.
自1989年以来,腹腔镜胆囊切除术已被广泛用作治疗胆结石疾病的方法。我们分析了该手术的引入与三个变量之间的关联:马里兰州胆囊切除术的实施率、常规临床实践中接受胆囊切除术患者的特征以及手术死亡率。
我们使用了马里兰州所有54家急症护理医院1985 - 1992年的医院出院数据,以确定开腹和腹腔镜胆囊切除术、接受这些手术患者的特征以及在实施这些手术的住院期间发生的死亡情况。经年龄调整后的胆囊切除术年率从1987 - 1989年每1000名州居民中的1.69例上升至1992年每1000名居民中的2.17例,增长了28%(P < 0.001)。与接受开腹胆囊切除术的患者相比,接受腹腔镜胆囊切除术的患者往往更年轻,患急性胆囊炎或胆总管结石的可能性更小,更可能是白人且拥有私人医疗保险或隶属于健康维护组织(P < 0.001)。尽管与腹腔镜胆囊切除术相关的手术死亡率低于开腹胆囊切除术(调整后的优势比为0.22;95%置信区间为0.13至0.37),且所有胆囊切除术的总死亡率从1989年的0.84%降至1992年的0.56%,但由于胆囊切除术率的增加,与胆囊切除术相关的手术死亡总数并无显著变化。
在马里兰州,尽管采用腹腔镜胆囊切除术使每次手术的总体手术死亡率降低了33%,但由于胆囊切除术总率增加了28%,与胆囊切除术相关的死亡总数并未下降。