Rosenmüller Mats, Haapamäki Markku M, Nordin Pär, Stenlund Hans, Nilsson Erik
Department of Surgery, Umeå University Hospital, Sweden.
BMC Gastroenterol. 2007 Aug 17;7:35. doi: 10.1186/1471-230X-7-35.
Epidemiological data on characteristics of patients undergoing open or laparoscopic cholecystectomy are limited. In this register study we examined characteristics and mortality of patients who underwent cholecystectomy during hospital stay in Sweden 2000 - 2003.
Hospital discharge and death certificate data were linked for all patients undergoing cholecystectomy in Sweden from January 1st 2000 through December 31st 2003. Mortality risk was calculated as standardised mortality ratio (SMR) i.e. observed over expected deaths considering age and gender of the background population.
During the four years of the study 43072 patients underwent cholecystectomy for benign biliary disease, 31144 (72%) using a laparoscopic technique and 11928 patients (28%) an open procedure (including conversion from laparoscopy). Patients with open cholecystectomy were older than patients with laparoscopic cholecystectomy (59 vs 49 years, p < 0.001), they were more likely to have been admitted to hospital during the year preceding cholecystectomy, and they had more frequently been admitted acutely for cholecystectomy (57% Vs 21%, p < 0.001). The proportion of women was lower in the open cholecystectomy group compared to the laparoscopic group (57% vs 73%, p < 0.001). Hospital stay was 7.9 (8.9) days, mean (SD), for patients with open cholecystectomy and 2.6 (3.3) days for patients with laparoscopic cholecystectomy, p < 0.001. SMR within 90 days of index admission was 3.89 (3.41-4.41) (mean and 95% CI), for patients with open cholecystectomy and 0.73 (0.52-1.01) for patients with laparoscopic cholecystectomy. During this period biliary disease accounted for one third of all deaths in both groups. From 91 to 365 days after index admission, SMR for patients in the open group was 1.01 (0.87-1.16) and for patients in the laparoscopic group 0.56 (0.44-0.69).
Laparoscopic cholecystectomy is performed on patients having a lower mortality risk than the general Swedish population. Patients with open cholecystectomy are more sick than patients with laparoscopic cholecystectomy, and they have a mortality risk within 90 days of admission for cholecystectomy, which is four times that of the general population. Further efforts to reduce surgical trauma in open biliary surgery are motivated.
关于接受开腹或腹腔镜胆囊切除术患者特征的流行病学数据有限。在这项登记研究中,我们调查了2000 - 2003年在瑞典住院期间接受胆囊切除术患者的特征及死亡率。
将2000年1月1日至2003年12月31日在瑞典接受胆囊切除术的所有患者的出院和死亡证明数据进行关联。计算死亡风险为标准化死亡比(SMR),即考虑背景人群年龄和性别的观察死亡数与预期死亡数之比。
在研究的四年中,43072例患者因良性胆道疾病接受胆囊切除术,其中31144例(72%)采用腹腔镜技术,11928例患者(28%)采用开腹手术(包括腹腔镜中转开腹)。开腹胆囊切除术患者比腹腔镜胆囊切除术患者年龄更大(59岁对49岁,p < 0.001),他们在胆囊切除术之前一年更有可能住院,并且更频繁地因胆囊切除术急性入院(57%对21%,p < 0.001)。开腹胆囊切除术组女性比例低于腹腔镜组(57%对73%,p < 0.001)。开腹胆囊切除术患者的住院时间为7.9(8.9)天,平均(标准差),腹腔镜胆囊切除术患者为2.6(3.3)天,p < 0.001。首次入院后90天内,开腹胆囊切除术患者的SMR为3.89(3.41 - 4.41)(均值和95%可信区间),腹腔镜胆囊切除术患者为0.73(0.52 - 1.01)。在此期间,胆道疾病占两组所有死亡的三分之一。首次入院后91至365天,开腹组患者的SMR为1.01(0.87 - 1.16),腹腔镜组患者为0.56(0.44 - 0.69)。
与瑞典普通人群相比,接受腹腔镜胆囊切除术患者的死亡风险较低。开腹胆囊切除术患者比腹腔镜胆囊切除术患者病情更重,并且他们在胆囊切除术后90天内的死亡风险是普通人群的四倍。有必要进一步努力减少开腹胆道手术中的手术创伤。