Miagostovich M P, Nogueira R M, Cavalcanti S M, Marzochi K B, Schatzmayr H G
Departamento de Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Rev Inst Med Trop Sao Paulo. 1993 Mar-Apr;35(2):149-54. doi: 10.1590/s0036-46651993000200006.
Laboratory studies were carried out on 3178 patients with signs and symptoms suggestive of dengue infection from April 1986 to December 1987 in the State of Rio de Janeiro, Brazil. The epidemic had two peaks following the first virus isolation and affected the inhabitants of 17 counties. Both sex and all age groups were affected. Dengue virus type 1 was isolated from 1039 sera and the number of confirmed cases was increased to 1874 (59%) by MAC-ELISA. Isolation rate confirmed cases reached 80% in the specimens obtained until the 4th day after the onset of disease and viraemia ranged from 10(3.0) to 10(8.5) TCID50/ml.
1986年4月至1987年12月期间，在巴西里约热内卢州对3178例有登革热感染迹象和症状的患者进行了实验室研究。疫情在首次病毒分离后出现两个高峰，影响了17个县的居民。男女及各年龄组均受影响。从1039份血清中分离出1型登革病毒，通过MAC - ELISA将确诊病例数增至1874例（59%）。在发病后第4天之前采集的标本中，确诊病例的分离率达80%，病毒血症范围为10(3.0)至10(8.5) TCID50/ml。
