Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA.
Viruses. 2011 Sep;3(9):1562-608. doi: 10.3390/v3091562. Epub 2011 Sep 1.
Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes (DENV-1-4). Although they share almost identical epidemiological features, they are genetically distinct. Phylogenetic analyses have revealed valuable insights into the origins, epidemiology and the forces that shape DENV evolution in nature. In this review, we examine the current status of DENV evolution, including but not limited to rates of evolution, selection pressures, population sizes and evolutionary constraints, and we discuss how these factors influence transmission, pathogenesis and emergence.
登革病毒（DENV）是目前全球热带地区最重要的虫媒病毒病原体，感染风险几乎涉及全球三分之一的人口。DENV 属于黄病毒科黄病毒属，包含四个血清型（DENV-1-4）。尽管它们具有几乎相同的流行病学特征，但在遗传学上是不同的。系统进化分析揭示了有关 DENV 在自然界中起源、流行病学和塑造其进化的力量的宝贵见解。在这篇综述中，我们检查了 DENV 进化的现状，包括但不限于进化率、选择压力、种群大小和进化约束，并讨论了这些因素如何影响传播、发病机制和出现。
