Wang G S, Han Z W
Department of Pharmacology, Inner Mongolia Medical College, Huhhot.
Yao Xue Xue Bao. 1993;28(8):572-6.
The protective action of Glycyrrhiza flavonoids (GF), the major components in the radix of Glycyrrhiza, on carbon tetrachloride-induced hepatotoxicity was investigated. The carbon tetrachloride-induced increases of serum glutamic-pyruvic transaminase and lactate dehydrogenase were significantly inhibited by GF dose-dependently. Carbon tetrachloride-induced necrosis in mice were ameliorated by GF pretreatment. Concomitantly, the carbon tetrachloride-induced elevation of MDA in the liver was lowered by GF. GF neither reduced the activities of the two enzymes in normal mouse sera nor directly inhibited the activities of the two enzymes in the serum. These findings suggest that the anti-lipid peroxidation effect of GF was contributed to its protective action against carbon tetrachloride-induced hepatotoxicity.
研究了甘草根中的主要成分甘草黄酮（GF）对四氯化碳诱导的肝毒性的保护作用。GF剂量依赖性地显著抑制了四氯化碳诱导的血清谷丙转氨酶和乳酸脱氢酶的升高。GF预处理改善了四氯化碳诱导的小鼠肝坏死。同时，GF降低了四氯化碳诱导的肝脏中丙二醛的升高。GF既不降低正常小鼠血清中这两种酶的活性，也不直接抑制血清中这两种酶的活性。这些发现表明，GF的抗脂质过氧化作用有助于其对四氯化碳诱导的肝毒性的保护作用。
