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[沙棘籽油对小鼠实验性肝损伤的保护作用]

[Protective action of seed oil of Hippophae rhamnoides L. (HR) against experimental liver injury in mice].

作者信息

Cheng T J

机构信息

Department of Pharmacology, Lanzhou Medical College.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 1992 Jul;26(4):227-9.

PMID:1302197
Abstract

Protection by seed oil of HR against hepatic injury induced by CCl4, ethyl alcohol and acetaminophen (AAP) on mice was studied in this paper. It was found that seed oil of HR markedly inhibited MDA formation of liver induced by CCl4, AAP and ethyl alcohol, seed oil 4.75 g/kg could lower SGPT levels induced by CCl4 and AAP. It blocked also depletion of GSH damaged liver induced by AAP. The mechanism of heptoprotective actions of HR seed oil might be related to anti-lipid peroxidation.

摘要

本文研究了辣木籽（HR）籽油对四氯化碳、乙醇和对乙酰氨基酚（AAP）诱导的小鼠肝损伤的保护作用。发现辣木籽（HR）籽油显著抑制四氯化碳、AAP和乙醇诱导的肝脏丙二醛（MDA）形成，4.75g/kg辣木籽（HR）籽油可降低四氯化碳和AAP诱导的谷丙转氨酶（SGPT）水平。它还能阻止AAP诱导的肝脏谷胱甘肽（GSH）耗竭。辣木籽（HR）籽油保肝作用的机制可能与抗脂质过氧化有关。

相似文献

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[Protective action of seed oil of Hippophae rhamnoides L. (HR) against experimental liver injury in mice].[沙棘籽油对小鼠实验性肝损伤的保护作用]
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Hippophae rhamnoides L. Fruits Reduce the Oxidative Stress in Human Blood Platelets and Plasma.沙棘果实可减轻人体血小板和血浆中的氧化应激。
Oxid Med Cell Longev. 2016;2016:4692486. doi: 10.1155/2016/4692486. Epub 2016 Jan 10.
2
Efficacy of Seabuckthorn (Hippophae rhamnoides) Oil vis-a-vis Other Standard Drugs for Management of Gastric Ulceration and Erosions in Dogs.沙棘油与其他标准药物对犬胃溃疡和糜烂的治疗效果对比
Vet Med Int. 2013;2013:176848. doi: 10.1155/2013/176848. Epub 2013 Jun 18.