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灵芝多糖对混合淋巴细胞反应中T细胞亚群及白细胞介素2产生的影响。

Effect of Ganoderma polysaccharides on T cell subpopulations and production of interleukin 2 in mixed lymphocyte response.

作者信息

Lei L S, Lin Z B

机构信息

Department of Pharmacology, Beijing Medical University.

出版信息

Yao Xue Xue Bao. 1992;27(5):331-5.

PMID:1442052
Abstract

Mixed lymphocyte response was used as a main model through all the experiments In a series of concentrations (25, 50, 100, and 200 micrograms/ml), Ganoderma polysaccharides (GL-B) promoted the production of interleukin 2 (IL-2) in a concentration-dependent manner after initiation of culture for 12 h and increased the total cell recovery as well as that of Lyt 2+ and L3T4+ cells after 4 days of culture. The data also show that the polysaccharides markedly enhanced the cytotoxicity of cytotoxic T lymphocytes, which was increased by 100% at the concentration of 200 micrograms/ml.

摘要

在所有实验中,混合淋巴细胞反应被用作主要模型。在一系列浓度(25、50、100和200微克/毫升)下,灵芝多糖(GL-B)在培养开始12小时后以浓度依赖的方式促进白细胞介素2(IL-2)的产生,并在培养4天后增加总细胞回收率以及Lyt 2+和L3T4+细胞的回收率。数据还表明,该多糖显著增强了细胞毒性T淋巴细胞的细胞毒性,在200微克/毫升的浓度下增加了100%。

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