Gupta J B, Prasad M, Kalra J, Prasad K
Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Angiology. 1994 Jan;45(1):25-36. doi: 10.1177/000331979404500104.
The effects of platelet-activating factor (PAF) on cardiac function and contractility and its mechanism of action are not fully understood. The authors investigated the effects of PAF in the absence or presence of a potent PAF antagonist CV-6209 on the cardiac function and contractility; lipid peroxidation product malondialdehyde (MDA), an indirect measure of oxygen free radicals; serum creatine kinase (CK); blood lactate; and pH in anesthetized dogs. CV-6209 (1 mg/kg, IV) did not produce significant changes in the various parameters studied. PAF (1 microgram/kg, IV) produced decreases in the cardiac function (cardiac index, left ventricular work index) and indices of cardiac contractility [(+) and (-) dp/dt, dp/dt at CPIP, (dp/dt)/IP, dp/dt at CPIP/IP, Vmax] and increases in the systemic and pulmonary vascular resistance. It also produced increases in cardiac MDA, serum CK, blood lactate, and H+ and decreases in blood pH and HCO3-. CV-6209 completely prevented the PAF-induced changes in the hemodynamic and biochemical parameters. These results suggest that PAF-induced cardiac depression may be due to PAF-induced release of oxyradicals from neutrophils and that PAF antagonist may be useful in counteracting the deleterious effects of PAF on the cardiovascular system.
血小板活化因子（PAF）对心脏功能和收缩性的影响及其作用机制尚未完全明确。作者研究了在有无强效PAF拮抗剂CV - 6209的情况下，PAF对麻醉犬心脏功能和收缩性的影响；脂质过氧化产物丙二醛（MDA），一种间接衡量氧自由基的指标；血清肌酸激酶（CK）；血乳酸；以及pH值。CV - 6209（1毫克/千克，静脉注射）对所研究的各项参数未产生显著变化。PAF（1微克/千克，静脉注射）使心脏功能（心脏指数、左心室作功指数）和心脏收缩性指标[（+）和（ - ）dp/dt、CPIP时的dp/dt、（dp/dt）/IP、CPIP/IP时的dp/dt、Vmax]降低，使体循环和肺血管阻力增加。它还使心脏MDA、血清CK、血乳酸和H⁺增加，使血pH值和HCO₃⁻降低。CV - 6209完全阻止了PAF诱导的血流动力学和生化参数变化。这些结果表明，PAF诱导的心脏抑制可能是由于PAF诱导中性粒细胞释放氧自由基所致，且PAF拮抗剂可能有助于对抗PAF对心血管系统的有害影响。
