Lin J P, Uttley W S
Royal Hospital for Sick Children, Edinburgh.
Arch Dis Child. 1993 Dec;69(6):689-92. doi: 10.1136/adc.69.6.689.
A five and a half year follow up of a girl with end organ resistant rickets is described. After failing to respond to high dose oral alfacalcidol (4 micrograms/kg/day) and calcium supplements, treatment for one year with domiciliary intra-atrial calcium infusions at 2 years of age induced a complete remission, which was maintained on subsequent high dose oral calcium supplement. Overnight infusions were well tolerated without adverse cardiovascular or renal sequelae or ectopic calcification. If the first three years of life are survived, the prognosis for a normal life on oral treatment is excellent.
本文描述了一名患有终末器官抵抗性佝偻病女孩的五年半随访情况。在对高剂量口服阿法骨化醇（4微克/千克/天）和钙剂补充治疗无反应后，该女孩在2岁时接受了为期一年的家庭心房内钙剂输注治疗，随后完全缓解，并通过后续高剂量口服钙剂得以维持。夜间输注耐受性良好，未出现不良心血管或肾脏后遗症或异位钙化。如果能度过生命的头三年，口服治疗下正常生活的预后极佳。
