Spiller H A, Ramoska E A, Krenzelok E P, Sheen S R, Borys D J, Villalobos D, Muir S, Jones-Easom L
Philadelphia Poison Control Center, PA.
Am J Emerg Med. 1994 Jan;12(1):43-5. doi: 10.1016/0735-6757(94)90195-3.
Bupropion (Wellbutrin; Burroughs Welcome Co, Research Triangle Park, NC) is a unique monocyclic antidepressant about which there is limited overdose information. A retrospective analysis of all bupropion ingestions reported to five regional poison control centers from 1989 through 1991 was conducted. There were 58 cases of bupropion ingestion and nine cases of combined bupropion and benzodiazepine ingestion. Sinus tachycardia was the only toxic cardiovascular effect noted, except for one case of hypotension in the bupropioin and benzodiazepine group. Neurological toxicity was commonly encountered and included lethargy, tremors, and seizures. Both benzodiazepines and phenytoin were efficacious in controlling seizures. Five cases of pure bupropion overdose had electrolytes reported. Serum potassium ranged from 2.6 to 4.2 mEq/L (mean, 3.3 mEq/L). In overdose, bupropion seems to lack major cardiovascular toxicity; however, it does manifest significant neurological toxicity.
安非他酮（威博隽；百时美施贵宝公司，北卡罗来纳州三角研究园）是一种独特的单环类抗抑郁药，关于其过量用药的信息有限。对1989年至1991年向五个地区毒物控制中心报告的所有安非他酮摄入病例进行了回顾性分析。有58例安非他酮摄入病例和9例安非他酮与苯二氮䓬联合摄入病例。除了安非他酮与苯二氮䓬组有1例低血压病例外，窦性心动过速是唯一观察到的中毒性心血管效应。神经毒性很常见，包括嗜睡、震颤和癫痫发作。苯二氮䓬类药物和苯妥英钠在控制癫痫发作方面均有效。有5例单纯安非他酮过量病例报告了电解质情况。血清钾浓度范围为2.6至4.2 mEq/L（平均3.3 mEq/L）。过量用药时，安非他酮似乎没有主要的心血管毒性；然而，它确实表现出明显的神经毒性。
