Hastrup N, Osterlind A, Drzewiecki K T, Hou-Jensen K
Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark.
Am J Dermatopathol. 1991 Aug;13(4):378-85. doi: 10.1097/00000372-199108000-00009.
We examined 512 malignant melanomas, representing all newly diagnosed cutaneous malignant melanomas, excluding lentigo maligna melanomas, from the period October 1, 1982 to March 31, 1985 occurring in the region of eastern Denmark in patients aged 20-79 years for the presence of dysplastic nevus remnants. Criteria for the diagnosis of a dysplastic nevus remnant include all the following changes (a) lentiginous or epithelioid melanocyte hyperplasia, (b) cytologic melanocyte atypia, (c) eosinophilic fibroplasia, (d) lamellar fibroplasia, and (e) lymphocytic infiltration in the dermis. Dysplastic nevus remnants were found in association with 34 (7%) of the evaluable 512 malignant melanomas. Fourteen (41%) of the remnants were of compound nevus type. In nine (27%) of the remnants, atypia was pronounced. Most (62%) dysplastic nevus remnants were contiguous to thin superficial spreading melanomas. We conclude from this population-based study that about 7% of malignant melanomas arise in prior dysplastic nevi.
我们检查了512例恶性黑色素瘤，这些病例代表了1982年10月1日至1985年3月31日期间丹麦东部地区所有新诊断的皮肤恶性黑色素瘤（不包括恶性雀斑样痣黑色素瘤），患者年龄在20至79岁之间，检查是否存在发育异常痣残余。发育异常痣残余的诊断标准包括以下所有变化：（a）雀斑样或上皮样黑素细胞增生，（b）黑素细胞细胞学异型性，（c）嗜酸性纤维增生，（d）板层状纤维增生，以及（e）真皮层淋巴细胞浸润。在可评估的512例恶性黑色素瘤中，有34例（7%）发现有发育异常痣残余。其中14例（41%）残余为复合痣类型。在9例（27%）残余中，异型性明显。大多数（62%）发育异常痣残余与浅表扩散型薄黑色素瘤相邻。基于这项以人群为基础的研究，我们得出结论，约7%的恶性黑色素瘤起源于先前的发育异常痣。
