Leunig M, Goetz A E, Gamarra F, Zetterer G, Messmer K, Jain R K
Institute for Surgical Research, University of Munich, Klinikum Grosshadern, Germany.
Br J Cancer. 1994 Jan;69(1):101-3. doi: 10.1038/bjc.1994.15.
The effect of photodynamic therapy (PDT) on interstitial fluid pressure (IFP), tumour volume and water content was measured in melanomas grown in hamsters. Unlike control tumours, treated tumours exhibited a 40-60% increase in volume at 1, 3 and 6 h post PDT. IFP also increased at 1 and 3 h after PDT, but decreased to 50% of control value after 24 h, presumably as a result of PDT-induced microcirculatory impairment.