Meechan J G, Seymour R A
Dental School, University of Newcastle upon Tyne.
Br J Oral Maxillofac Surg. 1993 Dec;31(6):360-5. doi: 10.1016/0266-4356(93)90191-x.
This review discusses the various sequelae that arise after third molar surgery and their use for assessing the efficacy of a variety of therapeutic measures. The surgical procedure provides an opportunity to investigate onset, depth, duration and possible systemic effects of local anaesthetic solutions. Also, the anxiety which often accompanies such surgery lends itself to the appraisal of different anxiolytic agents and sedation techniques. The immediate postoperative sequelae of pain, buccal swelling and trismus provides a useful clinical model for evaluating the efficacy of analgesics and anti-inflammatory drugs. Third molar tooth sockets are susceptible to infection and this propensity enables the assessment of different antibiotic regimens. A further advantage of the third molar model is its application for crossover studies, with the patient acting as their own control. Very few surgical procedures afford this facility, which further adds to the value of this model in clinical pharmacology.
本综述讨论了第三磨牙手术后出现的各种后遗症及其在评估多种治疗措施疗效方面的应用。手术过程为研究局部麻醉溶液的起效、深度、持续时间和可能的全身影响提供了机会。此外，此类手术常伴随的焦虑有助于评估不同的抗焦虑药物和镇静技术。术后即刻出现的疼痛、颊部肿胀和牙关紧闭后遗症为评估镇痛药和抗炎药的疗效提供了有用的临床模型。第三磨牙牙槽容易感染，这种倾向有助于评估不同的抗生素治疗方案。第三磨牙模型的另一个优点是可用于交叉研究，患者自身作为对照。很少有外科手术具备这种条件，这进一步增加了该模型在临床药理学中的价值。
