Battaglia G, Di Mario F, Pasini M, Donisi P M, Dotto P, Benvenuti M E, Stracca-Pansa V, Pasquino M
Servizio di Gastroenterologia ed Endoscopia Digestiva, OCR Venezia, Italy.
Ital J Gastroenterol. 1993 Oct;25(8):419-24.
Helicobacter pylori (Hp) is connected with active/chronic gastritis, gastric gastric and duodenal ulcer. It is not known whether exogenous factors are involved in Hp infection. The aim of this prospective study, performed on 286 consecutive subjects undergoing upper gastrointestinal endoscopy, was to evaluate the influence of smoking and alcohol consumption on Hp infection. For each patient the following parameters were taken into account: sex, age, smoking (no, < 10, > 10 cig/day) and alcohol (no, < 40, > 40 g ethanol/day) intake, antiulcer therapy (no, H2-blockers, omeprazole, sucralfate), presence of gastric or duodenal ulcer (DU). At least two biopsies from both the antrum and the corpus were obtained for histological examination; the gastritis was classified and scored according to the Sydney system.
chi-squared test (corrected), Fisher's exact test.
43 pts had Hp (27M, 16F; age 57.8 yrs, range 23-91), 47 Hp ++ (25M, 22F; age 61.1, range 19-86), 81 Hp + (48H, 33F; age 56, range 16-84), 115 Hp- (75M, 40F; age 57.8, range 19-84). Hp infection was found to be significantly correlated with presence of ulcer symptoms, gastritis, lymphoid follicles and, among DU patients, with active DU. The other parameters considered did not influence Hp infection. In conclusion smoking habits and alcohol consumption do not affect Hp infection of the stomach.
幽门螺杆菌（Hp）与活动性/慢性胃炎、胃溃疡和十二指肠溃疡有关。尚不清楚外源性因素是否参与Hp感染。本前瞻性研究对286例连续接受上消化道内镜检查的受试者进行，旨在评估吸烟和饮酒对Hp感染的影响。对于每位患者，考虑以下参数：性别、年龄、吸烟情况（不吸烟、每天<10支、每天>10支）和酒精摄入量（不饮酒、每天<40克乙醇、每天>40克乙醇）、抗溃疡治疗（未治疗、H2受体阻滞剂、奥美拉唑、硫糖铝）、胃溃疡或十二指肠溃疡（DU）的存在情况。从胃窦和胃体至少各取两块活检组织进行组织学检查；根据悉尼系统对胃炎进行分类和评分。
校正卡方检验、Fisher精确检验。
43例患者感染Hp（男性27例，女性16例；年龄57.8岁，范围23 - 91岁），47例Hp++（男性25例，女性22例；年龄61.1岁，范围19 - 86岁），81例Hp+（男性48例，女性33例；年龄56岁，范围16 - 84岁），115例Hp-（男性75例，女性40例；年龄57.8岁，范围19 - 84岁）。发现Hp感染与溃疡症状、胃炎、淋巴滤泡的存在显著相关，在DU患者中与活动性DU相关。所考虑的其他参数不影响Hp感染。总之，吸烟习惯和饮酒不影响胃部的Hp感染。
