伊朗的幽门螺杆菌感染：人口统计学、内镜和病理学因素。

Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors.

机构信息

Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Gastrointestinal and Liver Diseases Research Center, GI Cancer Screening and Prevention Research Center and Caspian Digestive Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

出版信息

BMC Gastroenterol. 2021 Sep 27;21(1):355. doi: 10.1186/s12876-021-01931-1.

DOI:10.1186/s12876-021-01931-1

PMID:34579657

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8477493/

Abstract

BACKGROUND

Helicobacter pylori (H. pylori) infection is the most important risk factor for gastritis and peptic ulcer. However, factors other than H. pylori are involved in its pathogenesis. In the current study, we aimed to compare the clinical manifestations and endoscopic and histopathological findings of patients with and without H. pylori infection.

METHODS

In this cross-sectional study, 233 patients with dyspepsia, referred for endoscopy, were examined regarding the presence of H. pylori infection. During an endoscopic exam, 5 biopsy specimens were taken from the stomach. The criteria for the presence of H. pylori infection was the presence and identification of bacteria in pathology. Two groups of H. pylori-positive and H. pylori-negative patients were compared regarding their demographic, endoscopic, and pathological findings.

RESULTS

Of 233 patients, 154 (66.1%) were non-smokers, 201 (86.3%) were not alcohol users, and 153 (65.7%) used tap water. The most common symptom, reported in 157 (67.4%) patients, was epigastric pain. There was a significant difference between patients with and without H. pylori infection in terms of the educational status, occupational status, family history of gastrointestinal cancer, and some gastrointestinal symptoms. Also, there was a significant relationship between the endoscopic and pathological findings of patients with H. pylori.

CONCLUSIONS

The results of the present study revealed that H. pylori infection was not associated with sex, alcohol consumption, or non-steroidal anti-inflammatory drug use. The role of H. pylori in the pathophysiology of peptic ulcer was clarified. Also, there was a significant difference in the endoscopic and pathological findings of patients with H. pylori.

摘要

背景

幽门螺杆菌（H. pylori）感染是胃炎和消化性溃疡的最重要危险因素。然而，除 H. pylori 之外，还有其他因素参与其发病机制。在本研究中，我们旨在比较 H. pylori 感染患者和非 H. pylori 感染患者的临床表现以及内镜和组织病理学发现。

方法

在这项横断面研究中，对因消化不良而接受内镜检查的 233 名患者检查 H. pylori 感染情况。在进行内镜检查时，从胃中取出 5 个活检标本。H. pylori 感染的存在标准是病理学中细菌的存在和鉴定。比较 H. pylori 阳性和 H. pylori 阴性两组患者的人口统计学、内镜和病理发现。

结果

在 233 名患者中，154 名（66.1%）为非吸烟者，201 名（86.3%）非酒精使用者，153 名（65.7%）使用自来水。最常见的症状（157 名患者，占 67.4%）是上腹痛。H. pylori 感染患者和非 H. pylori 感染患者在教育程度、职业状况、胃肠道癌症家族史和一些胃肠道症状方面存在显著差异。此外，H. pylori 患者的内镜和病理发现之间存在显著关系。