Ishii Y, Tanizawa H, Takino Y
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Biol Pharm Bull. 1993 Oct;16(10):1040. doi: 10.1248/bpb.16.1040.
As individual differences in sensitivity in the laxative activity of barbaloin were observed in rats, a selection test for barbaloin (31.1 mg/kg, p.o.) was carried out between 1989 and 1991. The annual percentages of rats exhibiting a reaction positive to barbaloin were almost constant (about 57%). We propose that rats positive to barbaloin should be selected for studies on the laxative effect of barbaloin.
