大鼠体内（+）-4-[4-（4-甲基苯基）苯甲氧基-1-哌啶基]丁酸（（+）-MPPB）处置的个体间差异。
Inter-individual differences of (+)-4-[4-(4-methylphenyl)phenylmethoxy-1-piperidinyl]butyric acid ((+)-MPPB) disposition in rats.
作者信息
Takahara E, Nagata O, Kato H, Ohta S, Hirobe M
机构信息
Research & Development Division, Hokuriku Seiyaku Co., Ltd., Fukui, Japan.
出版信息
Biol Pharm Bull. 1993 Oct;16(10):1057-9. doi: 10.1248/bpb.16.1057.
Inter-individual differences of drug plasma concentration were recognized in male Sprague-Dawley (SD) rats after a p.o. or i.v. administration of (+)-MPPB. Rats could be divided into two phenotypes, the rapid-metabolizing group (RM) and the slow-metabolizing group (SM). The hepatic clearance (CLliver) of RM was about 10 times larger than that of SM. Outbred SD(male, female), and Wistar(male) rats were mixtures of RM and SM. On the other hand, all inbred Lewis(male) rats were RM, and all inbred F344(male) and ACl(male) rats were SM.
在雄性Sprague-Dawley（SD）大鼠经口服或静脉注射（+）-MPPB后，观察到药物血浆浓度存在个体间差异。大鼠可分为两种表型，即快速代谢组（RM）和慢代谢组（SM）。RM组的肝脏清除率（CLliver）约为SM组的10倍。远交系SD（雄性、雌性）大鼠和Wistar（雄性）大鼠是RM和SM的混合群体。另一方面，所有近交系Lewis（雄性）大鼠均为RM型，所有近交系F344（雄性）和ACl（雄性）大鼠均为SM型。
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