Rabinowitz M B, Leviton A, Bellinger D
Marine Biological Laboratory, Woods Hole, Massachusetts.
Calcif Tissue Int. 1993 Nov;53(5):338-41. doi: 10.1007/BF01351840.
Because bones and permanent teeth accumulate lead, exfoliated deciduous teeth have been utilized as retrospective markers of cumulative exposure in epidemiological surveys. In this paper we describe four models of lead uptake by the coronal dentin of shed primary teeth, each with different assumptions and ramifications. Each model is characterized by different relationships between blood lead at several ages and tooth lead. Values observed in our cohort of normal Boston children are most compatible with models positing the largest lead contribution coming at older ages (i.e., closer to age at exfoliation). Characteristics of models incompatible with our data include (1) lead deposition only during initial calcification and (2) no loss or resorption of lead.
由于骨骼和恒牙会蓄积铅，因此在流行病学调查中，脱落的乳牙被用作累积暴露的回顾性标志物。在本文中，我们描述了乳牙冠部牙本质摄取铅的四种模型，每种模型都有不同的假设和影响。每个模型的特点是几个年龄阶段的血铅与牙铅之间存在不同的关系。在我们波士顿正常儿童队列中观察到的值与假设较大铅贡献来自较大年龄（即更接近脱落年龄）的模型最为相符。与我们的数据不相符的模型特征包括：（1）仅在初始钙化期间铅沉积；（2）铅无损失或再吸收。
