Turner G, Coates P, Porter S, Peters J R, Woodhead J S
Medical Biochemistry Department, University Hospital of Wales, Heath Park, Cardiff, UK.
Clin Chim Acta. 1993 Oct 29;220(1):19-30. doi: 10.1016/0009-8981(93)90003-m.
Urinary growth hormone (UGH) excretion was assessed in 44 adult subjects (10 control, 21 insulin dependent diabetics (Group I), 13 diabetics in poor glycaemic control (Group II)). UGH was markedly elevated in the diabetic population. The UGH excretion in (1) control subjects ranged from undetectable levels to 0.7 microU/h, mean 0.4, (2) Group I 73-422 microU/h, mean 250 and (3) Group II 10-5,283 microU/h, mean 705. There was a significant correlation between UGH excretion and albumin excretion rate (AER) (r = 0.38, P < 0.05) in the subjects studied although only 50% of patients had an AER of > 20 micrograms/min. A stronger correlation was observed between beta 2-microglobulin and UGH excretion (r = 0.7, P < 0.01). There was no significant change in the 6-h serum GH levels following treatment in the patients in Group II. However a 23-79% decline in UGH excretion was observed following improvement of glycaemic control, although UGH levels failed to revert to normal. We conclude that the major factor responsible for increased UGH excretion in DM appears to be reduced tubular reabsorption of the hormone. This test may therefore prove useful as an additional marker for screening for diabetic nephropathy and may help in the understanding of the contribution of renal tubular abnormalities to the nephropathic process.
对44名成年受试者（10名对照者、21名胰岛素依赖型糖尿病患者（第一组）、13名血糖控制不佳的糖尿病患者（第二组））的尿生长激素（UGH）排泄情况进行了评估。糖尿病患者群体中UGH显著升高。（1）对照者的UGH排泄量在检测不到至0.7微单位/小时之间，平均为0.4；（2）第一组为73 - 422微单位/小时，平均为250；（3）第二组为10 - 5283微单位/小时，平均为705。在所研究的受试者中，UGH排泄与白蛋白排泄率（AER）之间存在显著相关性（r = 0.38，P < 0.05），尽管只有50%的患者AER > 20微克/分钟。在β2 - 微球蛋白与UGH排泄之间观察到更强的相关性（r = 0.7，P < 0.01）。第二组患者治疗后6小时血清生长激素水平无显著变化。然而，血糖控制改善后观察到UGH排泄下降了23% - 79%，尽管UGH水平未能恢复正常。我们得出结论，糖尿病中UGH排泄增加的主要因素似乎是该激素的肾小管重吸收减少。因此，这项检测可能被证明是筛查糖尿病肾病的一个有用的额外标志物，并且可能有助于理解肾小管异常对肾病进程的影响。
